Preparation, Characterization and Study of Ethyl Pyruvate Aroyl Hydrazone Metal Complexes

Hydrazones derived from aroyl hydrazides and ethyl pyruvate namely; ethyl pyruvate benzoyl hydrazone (EPBH), ethyl pyruvate salicyloyl hydrazone (EPSH), ethyl pyruvate-2-furoyl hydrazone (EPFH) and ethyl pyruvate-2-thiophenoyl hydrazone (EPTH) have been synthesized and used in preparing the corresponding Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) complexes. The ligands undergo deprotonation forming neutral mononuclear octahedral bis-complexes of the type [M(L-H)2] where L-H = deprotonated EPBH, EPSH, EPFH or EPTH, acting as uni-negative tridentate ligands. The complexes isolated were characterized by elemental analyses, IR, electronic, 1H-NMR spectra, molar conductance and magnetic susceptibility measurements. The bonding and probable structure of the complexes are discussed on the basis of the spectral and magnetic data. The ligands, as well as some of their complexes, screened against Gram-positive and Gram-negative bacteria.